Table 3 Descriptive statistics of secondary outcomes, global cognition, health-related quality of life, and subjective health estimation

Mood

COV,n-COV

Mean (SD)

Mean (SD)

Mean (SD)

Above normal range (abnormal) in %

Anxiety

Baseline

14, 13

62.4 (10.3)

62.4 (11.0)

62.4 (10.0)

71.4

53.8

Visit 1

14, 15

59.4 (9.7)

60.8 (11.2)

58.1 (8.2)

57.1

40.0

Visit 2

10, 9

55.8 (9.9)

53.9 (11.1)

57.9 (8.4)

30.0

33.3

Visit 3

15, 11

53.0 (10.5)

51.5 (11.1)

55.0 (9.7)

13.3

36.4

Depression

Baseline

14, 13

58.2 (14.8)

59.3 (14.6)

56.9 (15.5)

42.9

46.2

Visit 1

14, 15

54.8 (12.8)

53.9 (11.9)

55.6 (13.9)

35.7

53.3

Visit 2

10, 9

53.4 (13.2)

48.6 (12.9)

58.8 (11.9)

30.0

55.6

Visit 3

15, 11

43.2 (13.4)

43.0 (13.6)

43.5 (13.7)

13.3

18.2

Functional scores

COV,n-COV

Median [IQR]

Median [IQR]

Median [IQR]

Below cut-off in %

BI

Baseline

15, 15

15 [5, 31.3]

15 [5, 45]

20 [10, 25]

93.3

100

Visit 1

14, 15

27.5 [15, 45]

35 [15, 48.8]

20 [15, 40]

85.7

93.3

Visit 2

10, 1

50 [40, 58.8]

55 [20, 61.3]

45 [40, 55]

80.0

100

Visit 3

15, 13

65 [60, 72.5]

65 [60, 75]

65 [57.5, 67.5]

40.0

30.8

ER-BI

Baseline

15, 15

− 150 [− 150, − 87.5]

− 150 [− 150, 0]

− 100 [− 150, − 100]

–

–

Visit 1

14, 15

− 100 [− 150, − 37.5]

− 100 [− 150,0]

− 100 [− 150, − 100]

–

–

Visit 2

10, 1

− 50 [− 100, 0]

0 [− 112.5, 0]

− 50 [− 62.5, 0]

–

–

Visit 3

15, 13

0 [− 50, 0]

0 [− 50, 0]

0 [− 50, 0]

–

–

EBI

Baseline

15, 12

85 [75, 90]

85 [80, 90]

75 [70, 90]

–

–

Visit 1

14, 14

85 [75, 90]

85 [83.8, 90]

77.5 [73.8, 90]

–

–

Visit 2

10, 1

90 [80, 90]

90 [80, 90]

85 [75, 90]

–

–

Visit 3

15, 13

90 [80, 90]

90 [85, 90]

90 [75, 90]

–

–

mRS

Baseline

15, 15

4 [4, 5]

4 [3, 5]

4 [4, 5]

86.7

93.3

Visit 1

14, 15

4 [3, 4]

4 [2.8, 4]

4 [4]

78.6

100.0

Visit 2

10, 1

4 [3, 4]

3.5 [3, 4]

4 [3, 4]

90.0

90.0

Visit 3

15, 13

2 [1.3, 3]

2 [1, 3]

3 [2, 3.5]

40.0

53.9

Other

COV,n-COV

Mean (SD)

Mean (SD)

Mean (SD)

Below cut-off in %

MoCA*

Baseline

13, 14

22.7 (3.5)

23.5 (3.8)

21.9 (3.2)

69.2

85.7

Visit 3

13, 9

24.9 (2.6)

25.6 (2.3)

23.9 (2.8)

53.8

77.8

EQ5D5L

–

–

EQ index

visit 1

14, 14

0.6 (0.3)

0.6 (0.3)

0.6 (0.4)

–

–

visit 3

15, 10

0.8 (0.2)

0.8 (0.2)

0.8 (0.1)

–

–

VAS-score

visit 1

14, 14

50.1 (21.0)

47.2 (20.0)

52.9 (22.2)

–

–

visit 3

15, 10

67.4 (17.1)

67.2 (18.5)

67.8 (15.6)

–

–

How many % regained (visit 3)

Subjectively fully (100%) recovered in %

Of physical health

13, 9

74 [60, 80]

68 [55, 77.5]

80 [67.5, 80]

0

0

Of cognitive health

13, 9

99 [83.8, 100]

98 [82.5, 100]

100 [80, 100]

46.2

55.6