Table 1 Main characteristics of the ‘baseline cohort’ by anticoagulation scheme
DOAC (N = 557) | VKA (N = 251) | Non-OAC (N = 123) | p values | |||||
|---|---|---|---|---|---|---|---|---|
Variable | N | Value | N | Value | N | Value | DOAC vs. non-OAC | VKA vs. non-OAC |
Age in years, mean (SD) | 577 | 79.2 (8) | 251 | 79.3 (7.5) | 123 | 78.0 (9.5) | 0.216 | 0.184 |
Female sex, n (%) | 577 | 277 (48) | 251 | 95 (37.8) | 123 | 57 (46.3) | 0.737 | 0.116 |
CHA2DS2VASc, median (IQR) | 573 | 4 (3–6) | 250 | 4 (3–5) | 121 | 4 (3–5) | 0.013 | 0.339 |
HAS-BLED, median (IQR) | 572 | 2 (2–3) | 246 | 2 (2–3) | 121 | 2 (2–3) | 0.138 | 0.716 |
Antiplatelet therapy, n (%) | 567 | 64 (11.3) | 247 | 21 (8.5) | 118 | 53 (44.9) | < 0.0001 | < 0.0001 |
SBP at admission, mmHg, median (IQR) | 537 | 170 (150–190) | 235 | 167 (149–190) | 116 | 163 (149–200) | 0.748 | 0.830 |
SBP at 24 h, mmHg, median (IQR) | 423 | 138 (120–150) | 187 | 130 (120–148) | 105 | 135 (120–150) | 0.705 | 0.401 |
Reversal treatment, n (%) | ||||||||
None | 577 | 239 (41.4) | 251 | 58 (23.1) | ||||
PCC | 577 | 288 (49.9) | 251 | 193 (76.9) | ||||
Specific† | 577 | 50 (8.7) | ||||||
Surgical treatment, n (%) | ||||||||
Haematoma evacuation | 577 | 26 (4.5) | 251 | 16 (6.4) | 123 | 4 (3.3) | 0.533 | 0.207 |
Ventricular drainage | 577 | 51 (8.8) | 251 | 29 (11.6) | 123 | 9 (7.3) | 0.584 | 0.203 |
NIHSS at admission, median (IQR) | 545 | 10 (4–20) | 238 | 10 (4–20) | 122 | 9 (4–18) | 0.680 | 0.497 |
modified Rankin scale score, median (IQR) | ||||||||
Pre-stroke | 506 | 1 (0–3) | 217 | 1 (0–2) | 104 | 1 (0–3) | 0.192 | 0.019 |
At admission | 562 | 4 (3–5) | 249 | 4 (3–5) | 121 | 4 (3–5) | 0.486 | 0.882 |
Discharge | 561 | 5 (3–6) | 245 | 4 (3–6) | 120 | 4 (3–5) | 0.171 | 0.648 |
Death during acute stay, n (%) | 577 | 174 (30.2) | 251 | 74 (29.5) | 123 | 28 (22.8) | 0.101 | 0.171 |
Mortality at 3 months, n (%) | 492 | 249 (50.6) | 218 | 101 (46.3) | 101 | 44 (43.6) | 0.197 | 0.644 |