Fig. 1

Effect of piracetam on the Orgogozo stroke severity/impairment scale (high scores indicate recovery) in acute ischaemic stroke. Data were extracted from the PASS publication; [19] the PASS >  = 7 h data were estimated from the publication. No data were available for PASS-II. The mean difference (fixed effect) was calculated in Cochrane REVMAN software; a mean difference < 0 implies a good outcome. A positive mean difference implies a good outcome. The overall effect of piracetam was neutral. The post hoc interaction test between early (< /LT 7 h) and later (> = /GTE) treatment was significant. The component of interest (randomisation within 7 h) was non-significant. The results of the PASS-II follow-up trial are unpublished