Table 1 Demographic and baseline characteristics
Patients receiving thrombectomy (n = 807) | Low HDL-C (< 1.15mmol/L) (n = 386) | High HDL-C (≥ 1.15 mmol/L) (n = 369) | p-value | |
|---|---|---|---|---|
Demographic Characteristics | ||||
Age, years (median [IQR]) | 77 [66, 84] | 75 [64, 83] | 78 [69, 84] | 0.018 |
Sex, female (n, %) | 420, 52.00 | 155, 40.16 | 235, 63.69 | 0.000 |
Premorbid condition | 0.885 | |||
Independent (n, %) | 587, 72.73 | 283, 73.32 | 269, 72.90 | |
Needs assistance (n, %) | 224, 27.76 | 103, 26.68 | 100, 27.10 | |
Chronic disease (n, %) | 0.104 | |||
No organ system | 501, 62.08 | 230, 59.59 | 238, 64.50 | |
1 Organ system | 220, 27.26 | 107, 27.72 | 100, 27.10 | |
2 Organ systems | 80, 9.91 | 42, 10.88 | 30, 8.13 | |
3 Organ systems | 9, 1.12 | 7, 1.81 | 1, 0.27 | |
Cardiovascular Risk Factors | ||||
Arterial hypertension (n, %) | 720, 89.22 | 347, 89.90 | 323, 87.53 | 0.164 |
Diabetes mellitus (n, %) | 232, 28.75 | 137, 35.49 | 80, 21.68 | 0.000 |
HbA1c, % (median [IQR]) | 5.8 [5.4, 6.3] | 5.9 [5.5, 6.4] | 5.7 [5.4, 6.1] | 0.000 |
LDL, mg/dl (median [IQR]) | 2.28 [1.71, 2.99] | 2.17 [1.64, 2.88] | 2.41 [1.81, 3.04] | 0.004 |
HDL, mg/dl (median [IQR]) | 1.15 [0.93, 1.43] | 0.93 [0.78, 1.05] | 1.41 [1.27, 1.58] | |
Preventive Pharmacological Treatment | ||||
Statin (n, %) | 262, 32.47 | 136, 35.23 | 114, 30.89 | 0.112 |
Antiplatelet therapy (n, %) | 205, 25.40 | 105, 27.20 | 90, 24.39 | 0.194 |
Dual Antiplatelet therapy (n, %) | 7, 0.87 | 3, 0.78 | 3, 0.81 | |
Aspirin monotherapy (n, %) | 191, 23.67 | 96, 24.87 | 87, 23.58 | |
Clopidogrel monotherapy (n, %) | 7, 0.87 | 6, 1.55 | 0,0 | |
Stroke Characteristics | ||||
Wake-up | 163, 20.20 | 72, 18.65 | 80, 21.68 | 0.179 |
NIHSS at baseline (median, [IQR]) | 15 [10, 19] | 15 [11, 19] | 15 [10, 18] | 0.043 |
mRS at baseline (median [IQR]) | 5 [4, 5] | 5 [4, 5] | 5 [4, 5] | 0.088 |
ASPECTS (median [IQR]) | 7 [6, 9] | 7 [6, 9] | 8 [6, 9] | 0.401 |
Occlusion side, left (n, %) | 410, 50.81 | 205, 53.11 | 172, 46.61 | 0.068 |
Occlusion site (n, %) | 0.008 | |||
ICA intracranial | 9, 1.12 | 6, 1.55 | 3, 0.81 | |
Carotid L or isolated M1 | 662, 82.03 | 326, 84.46 | 290, 78.59 | |
M1/2-junction or isolated M2 | 139, 17.14 | 53, 13.73 | 76, 20.60 | |
Carotid T | 80, 9.91 | 39, 10.10 | 31, 8,40 | |
Tandem | 105, 13.01 | 62, 16.06 | 33, .8.94 | |
Leptomeningeal collaterals on DSA (n, %) | 673, 83.40 | 312, 80.83 | 313, 84.82 | 0.052 |
TOAST Classification (n, %) | 0.001 | |||
Large artery atherosclerosis | 150, 18.59 | 87, 22.54 | 53, 14.36 | |
Cardioembolism | 474, 58.74 | 220, 56.99 | 220, 59.62 | |
Small vessel occlusion | 0, 0.00 | 0, 0.00 | 0, 0.00 | |
Stroke of other determined aetiology | 23, 2.85 | 9, 2.33 | 10, 2.71 | |
Stroke of undetermined aetiology | 161, 19.95 | 67, 17.36 | 86, 23.30 | |
Interventions (n, %) | ||||
Intravenous thrombolysis with rtPA | 403, 49.94 | 194, 50.26 | 187, 50.68 | 0.498 |
Drip and ship | 529, 65.55 | 265, 68.65 | 227, 61.52 | 0.024 |
Carotid stent (emergency) | 87, 10.78 | 54, 13.99 | 27, 7.32 | 0.002 |
Sedative Regimen (n, %) | 0.004 | |||
Conscious sedation | 232, 28.75 | 95, 24.61 | 123, 33.33 | |
General anaesthesia | 562, 69.64 | 284, 73.58 | 238, 64.50 | |
Procedural Times, min (median [IQR]) | ||||
Onset unclear (n, %) | 123, 15.24 | 53, 13.73 | 58, 15.72 | 0.397 |
Onset-to-needle | 105 [80, 135] | 109.5 [85, 138] | 105 [79, 134] | 0.470 |
Onset-to-groin | 240 [173, 298] | 242.2 [174, 298] | 235 [171, 300] | 0.967 |
Onset-to-recanalization | 302 [234, 364] | 301 [239, 367] | 297 [228, 360] | 0.318 |