Fig. 1

Disease burden in patients by categories of disease control (MANAGE-PD tool). Panels A, D: mean values with standard deviation as whiskers. Panels B and C: percentages. Dyskinesia duration: dyskinesia anytime during the day: at least mildly disabled. “Off” duration: % of the day with “Off” time. The number of patients is shown at the bottom of the bars. NMSS, Non-Motor Symptoms Scale (NMSS); PDQ-8, 8-item Parkinson’s disease Questionnaire; UPDRS, Unified PD Rating Scale (UPDRS parts II-IV)