Table 1 Baseline characteristics and stroke features
AIS-patients treated with IVT (n = 276) | TNK (n = 138) | rt-PA (n = 138) |
|---|---|---|
Age, y; median (IQR) | 77 (63–85) | 74 (59–82) |
- Patients aged > 80 years; n (%) | 39 (28%) | 51 (37%) |
Female sex; n (%) | 60 (44%) | 68 (49%) |
Prior medical history;n(%) | ||
Premorbid mRS; median (IQR) | 0 (0–2) | 0 (0–3) |
- Premorbid mRS 0–1 | 101 (73%) | 89 (65%) |
Heart failure | 11 (8%) | 19 (14%) |
Hypertension | 93 (67%) | 105 (76%) |
Diabetes mellitus Type II | 27 (20%) | 33 (24%) |
Previous Stroke or TIA | 29 (21%) | 33 (24%) |
Vascular diseases* | 21 (15%) | 30 (22%) |
Atrial fibrillation | 13 (9%) | 23 (17%) |
CHA2DS2-VASc-Score; median (IQR) | 3 (2–4) | 4 (2–5) |
Comedication;n(%) | ||
OAC intake | 17 (12%) | 17 (12%) |
Single antiplatelet therapy | 44 (32%) | 45 (33%) |
Dual antiplatelet therapy | 2 (1%) | 0 (0%) |
Stroke characteristics | ||
NIHSS on admission; median (IQR) | 6 (3–11) | 7 (4–12) |
Stroke severity; n (%) | ||
NIHSS 0 | 9 (7%) | 2 (1%) |
Mild (NIHSS 1–4) | 47 (34%) | 47 (34%) |
Moderate (NIHSS 5–15) | 62 (45%) | 68 (49%) |
Severe (NIHSS ≥ 16) | 20 (15%) | 20 (15%) |
Symptom-onset-to-door, min; median (IQR)** | 80 (60–143) | 78 (56–119) |
- Early time window(≤ 4.5h); n (%) | 99 (72%) | 104 (75%) |
- Late time window (> 4.5h); n (%) | 39 (28%) | 34 (25%) |
- Unknown time window; n (%) | 0 (0%) | 1 (1%) |
Large vessel occlusion present; n (%) | 40 (29%) | 45 (33%) |
- Carotid artery; n (%) | 6 (15%) | 8 (18%) |
- Carotid T; n (%) | 2 (5%) | 7 (16%) |
- M1; n (%) | 13 (33%) | 15 (33%) |
- M2; n (%) | 17 (43%) | 11 (24%) |
- Basilar artery; n (%) | 1 (3%) | 2 (4%) |
- Vertebral artery; n (%) | 1 (3%) | 2 (4%) |
Endovasular thrombectomy; n (%) | 31 (78%) | 33 (73%) |
Initial imaging modality;n(%) | ||
NCCT | 4 (3%) | 5 (4%) |
PCT | 130 (94%) | 130 (94%) |
MRI | 1 (1%) | 2 (1%) |
Imaging performed externally | 3 (2%) | 1 (1%) |
IVT based on imaging modality;n(%) | ||
NCCT-based | 70 (51%) | 72 (52%) |
PCT-based | 66 (48%) | 64 (46%) |
MRI-based | 2 (1%) | 2 (1%) |
Toast classification;n(%) | ||
Microangiopathy | 22 (17%) | 12 (9%) |
Macroangiopathy | 25 (19%) | 37 (28%) |
Cardioembolic | 40 (31%) | 47 (36%) |
Unknown | 38 (30%) | 32 (24%) |
Other | 4 (3%) | 4 (3%) |