Skip to main content

Table 2 Motor neuron signs and symptoms (according to gold Coast criteria [41])

From: Motor phenotypes of amyotrophic lateral sclerosis – a three-determinant anatomical classification based on the region of onset, propagation of motor symptoms, and the degree of upper and lower motor neuron dysfunction

Region

Upper motor neuron (UMN)

Lower motor neuron (LMN)

Head

• slowed, poorly coordinated voluntary movement of the tongue (reduced range of motion, difficulty with lateral movements)

• hyperreflexia of mandibular reflex (jaw jerk positive)

• palatal spasticity (abnormal, uncoordinated or excessive movement of the palate)

• snout reflex (pathological reflex)

• tongue wasting

• palatal weakness and fasciculations

Arm

• Increased velocity-dependent tone (spasticity) in hand and arm

• slowed, poorly coordinated voluntary movement in hand, arm or shoulder

• hyperreflexia

• preserved reflexes in wasted or weak muscles

• spread of reflexes to adjacent muscles

• Hoffman´s sign (pathological reflex)

• weakness of hand, arm or shoulder muscles and muscle wasting

• absent reflexes

Trunk

• slowed, poorly coordinated voluntary movement during respiration or trunk movements

• pathological paraspinal and abdominal reflexes

• weakness of paraspinal, costal and abdominal muscles and muscle wasting

Leg

• Increased velocity-dependent tone (spasticity) in foot, leg or hip

• slowed, poorly coordinated voluntary movement of foot, leg or hip

• hyperreflexia

• preserved reflexes in wasted or weak muscles

• spread of reflexes to adjacent muscles

• Babinski sign (commonly not present)

• crossed adductor reflex

• weakness of foot, leg or hip muscles and muscle wasting

• absent reflexes