Fig. 2

(A) Lesion Heatmap. Heatmap of lesions included in the analysis (n = 70, maximum overlap = 23) overlaid on axial slices of an ex-vivo MNI space template acquired at 7T with 100 μm resolution [21], cold colours indicate less patients overlap, while warm colours indicate more patients overlap at a given voxel. (B) Striatal network. Seed-based connectivity using normative connectome (n = 1000 healthy subjects) [14], employing a striatal mask from the Harvard Oxford Subcortical Structural Atlas [12, 13] as the seed. Positive (red-yellow) and negative (blue-light blue) connections based on BOLD signal across the 1000 subjects is shown. Example of two patient lesions from the non-striatal group are shown in white (lesion of patient with GDS-30 and PTSS-10 values above the cut-off for depression and PTSD), pointed by white arrow, and black* (lesion of patient with GDS-30 and PTSS-10 values below clinical cut-off), pointed by black arrow. *Only visible in first two slices